If you believe the video, the film is based on the story of Dennis Depue, who murdered his wife Mary and then fled the state. The event was covered by Unsolved Mysteries and Depue was caught the night the episode aired after his girlfriend and friends reported him to authorities. Depue ended up committing suicide in his car after the pursuit came to a halt.
What makes the stories similar is the way the killers were discovered, which involves investigating an abandoned building. Thanks to Bloody Disgusting for keeping me up all night tonight.